ACOG SMFM Practice Advisory: Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and Mortality

ACOG, SMFM, AS Bryant, AG Cahill, JA Kuller, JM Louis, MA Turrentine2021

ACOG, SMFM, AS Bryant, AG Cahill, JA Kuller, JM Louis, MA Turrentine — 2021

Low-dose aspirin has been used during pregnancy most commonly to prevent or delay the onset of preeclampsia 1. The previous recommendation from the American College of Obstetricians and Gynecologists (ACOG), the Society for Maternal-Fetal Medicine (SMFM), and the U.S. Preventive Services Task Force (USPSTF) has been for low-dose aspirin (81 mg/d) prophylaxis after 12 weeks of gestation in pregnant individuals at high risk of preeclampsia and suggested low-dose aspirin prophylaxis in pregnant individuals with more than one moderate-risk factor 1,2. ACOG and SMFM also have provided more detailed information around timing, recommending that low-dose aspirin be initiated between 12 weeks and 28 weeks of gestation (optimally before 16 weeks) and continued daily until delivery 

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hypertensive disorders, preeclampsia, care of high-risk pregnancy, hypertension
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